Soundcheck: Nothing, Let Me Lie, Friday, Walls of the Cave
SET 1: After Midnight, The Sloth, Alumni Blues > Letter to Jimmy Page > Alumni Blues, Mellow Mood, Access Me, Llama, All of These Dreams, The Curtain With > Scent of a Mule, A Song I Heard the Ocean Sing, It's Ice > Walls of the Cave
SET 2: Possum > Light > Mike's Song > Simple > Makisupa Policeman -> Night Nurse -> Makisupa Policeman > The Wedge, Ghost -> The Mango Song > Weekapaug Groove -> Llama Reprise
ENCORE: Show of Life
 "From Goddard College" added to lyrics.
 "Woke up this morning with a policeman at my door all I could do was shrug, and go back in my bedroom and smoke another nug" lyrics.
 Phish debut.
After Midnight was played for the first time since December 31, 1999 (206 shows). In Alumni, Trey added "from Goddard College" after the final "'cause I got a degree" lyric. Makisupa included the lyrics "Woke up this morning with a policeman at my door all I could do was shrug, and go back in my bedroom and smoke another nug." This show featured the Phish debut of Night Nurse; original artist Gregory Isaacs passed away the night before, October 25, 2010. Weekapaug was heavily teased by Trey in Mango before the segue into Weekapaug itself. Weekapaug subsequently contained a Can't You Hear Me Knocking jam, which featured lyrics from Ghost and Night Nurse, and was unfinished.